Facial rejuvenation treatments last for different times. Generally speaking, dermal fillers will last longer than anti-wrinkle injections. Also, the more movement there was in the area originally, the more quickly the area will need to be re-treated. For example, anti-wrinkle injections for forehead and frown lines generally last for 3-6 months. However, dermal fillers placed to enhance the cheeks can last for 2 or more years.